CLINICAL EVIDENCE · PEER-REVIEWED
The science behind every product.
STUDIES
12
PATIENTS
1,500+
HEALING
+42%
COST
−28%
ADVERSE EVENTS
0
Peer-reviewed studies, literature reviews, and case data supporting SEFM collagen, placental biologics, and the protocols our partners deploy. Full PDFs available on request.
RESEARCH LIBRARY
The evidence supporting SEFM protocols.
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2024 · LITERATURE REVIEW
Literature Review
Hydrolyzed Versus Native Collagen in Management of Acute Surgical Wounds: A Literature Review
An analysis of collagen bioavailability in acute wound applications, contrasting native triple-helix structures with hydrolyzed sequences.
14 PAGES
2024 · MASTER REFERENCE
Literature Review
Collagen in Modern Wound Care: A Comprehensive Master Reference
A detailed compendium of collagen metrics, processing methodologies, and clinical application guidelines for modern healthcare providers.
68 PAGES
Case Series
Real-World Outcomes: SEFM Protocol Implementation Across 8 Facilities
2025 · MULTICENTER DATA
Observation of 400+ clinical applications post-integration of SEFM software verification and biologic protocols in various SNF environments.
31 PAGES
2023 · CLINICAL TRIAL
Clinical Trial
Collagen Powder in Chronic Wound Management: A Prospective Clinical Study
A multicenter study evaluating the efficacy of bovine-derived collagen powder in accelerating epithelialization for stage III/IV pressure ulcers.
22 PAGES
2024 · TIGER 2 TRIAL
Clinical Trial
Placental Skin Substitute (TIGER 2) in Diabetic Foot Ulcers
A prospective randomized trial measuring the closure rates of recalcitrant DFUs when treated with placental-derived matrices compared to standard debridement.
18 PAGES
Case Series
Biologic Integrity Report: 1,500+ Placental Matrix Applications
2025 · APPLICATION REPORT
A longitudinal summary of adverse event rates (0) and healing trajectories across a large-scale deployment of amniotic placental biologics.
44 PAGES
OUTCOMES MEASURED
What we track across every SEFM deployment.
+42%
VLU healing rate vs standard of care, 12-week window
−28%
Total episode-of-care cost
1,500+
Placental matrix applications
0
Reported immunogenic response events
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CUSTOM DATA SUMMARIES AVAILABLE ON REQUEST